Target：Cdc5L

Fields：Spliceosome

Gene Name：CDC5L

Protein Name：Cell division cycle 5-like protein

Human Gene Id：988

Human Swiss Prot No：Q99459

Mouse Gene Id：71702

Mouse Swiss Prot No：Q6A068

Rat Gene Id：85434

Rat Swiss Prot No：O08837

Immunogen：The antiserum was produced against synthesized peptide derived from human CDC5L. AA range:721-770

Specificity：Cdc5L Polyclonal Antibody detects endogenous levels of Cdc5L protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CDC5L;KIAA0432;PCDC5RP;Cell division cycle 5-like protein;Cdc5-like protein;Pombe cdc5-related protein

Molecular Weight(Da)：92kD

Background： The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008],

Function：disease:A chromosomal aberration involving CDC5L is found in multicystic renal dysplasia. Translocation t(6;19)(p21;q13.1) with USF2.,function:DNA-binding protein involved in cell cycle control. May act as a transcription activator. Also seems to be involved in the second catalytic step of pre-mRNA splicing.,PTM:Phosphorylated; which enhances interaction with PPP1R8.,similarity:Belongs to the CEF1 family.,similarity:Contains 2 HTH myb-type DNA-binding domains.,subcellular location:May shuttle between cytoplasm and nucleus.,subunit:Homodimer. Interacts with DAPK3 (By similarity). Binds to DNA. Binds to adeno-pre-mRNA in an ATP-stimulated manner. Belongs to the spliceosome complex. Part of a spliceosomal 'core' complex consisting of CDC5L, PLRG1, SPF27, CCAP1, CCAP3 and CCAP6. Interacts with PLRG1, Lodestar/TTF2, and NIPP1/PPP1R8. Identified in the spliceosome C complex, at least composed

Subcellular Location：Nucleus . Nucleus speckle . Cytoplasm . May shuttle between cytoplasm and nucleus. .

Expression：Ubiquitously expressed in both fetal and adult tissues.