Target：LYPLA1
Fields：Glycerophospholipid metabolism;Choline metabolism in cancer
Gene Name：LYPLA1
Protein Name：Acyl-protein thioesterase 1
Human Gene Id：10434
Human Swiss Prot No：O75608
Mouse Gene Id：18777
Mouse Swiss Prot No：P97823
Rat Gene Id：25514
Rat Swiss Prot No：P70470
Immunogen：The antiserum was produced against synthesized peptide derived from human LYPLA1. AA range:51-100
Specificity：LYPLA1 Polyclonal Antibody detects endogenous levels of LYPLA1 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：LYPLA1;APT1;LPL1;Acyl-protein thioesterase 1;APT-1;hAPT1;Lysophospholipase 1;Lysophospholipase I;LPL-I;LysoPLA I
Observed Band(KD)：25kD
Background： This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013],
Function：catalytic activity:Palmitoyl-protein + H(2)O = palmitate + protein.,function:Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Also has low lysophospholipase activity.,similarity:Belongs to the AB hydrolase 2 family.,subunit:Homodimer.,
Subcellular Location：Cytoplasm . Cell membrane . Nucleus membrane . Endoplasmic reticulum . Shows predominantly a cytoplasmic localization with a weak expression in the cell membrane, nuclear membrane and endoplasmic reticulum. .
Expression：Platelets.
