Target：RORγ

Fields：Th17 cell differentiation;Circadian rhythm;Inflammatory bowel disease

Gene Name：RORC

Protein Name：Nuclear receptor ROR-gamma

Human Gene Id：6097

Human Swiss Prot No：P51449

Mouse Gene Id：19885

Mouse Swiss Prot No：P51450

Immunogen：The antiserum was produced against synthesized peptide derived from human RORG. AA range:71-120

Specificity：RORγ Polyclonal Antibody detects endogenous levels of RORγ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RORC;NR1F3;RORG;RZRG;Nuclear receptor ROR-gamma;Nuclear receptor RZR-gamma;Nuclear receptor subfamily 1 group F member 3;Retinoid-related orphan receptor-gamma

Observed Band(KD)：58kD

Background： The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Function：function:Orphan nuclear receptor.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,tissue specificity:Highly expressed in skeletal muscle.,

Subcellular Location：Nucleus .

Expression：Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2 is primarily expressed in immature thymocytes.