Target：mAChR M1

Fields：Calcium signaling pathway;cAMP signaling pathway;Neuroactive ligand-receptor interaction;PI3K-Akt signaling pathway;Cholinergic synapse;Regulation of actin cytoskeleton;Alzheimer disease;Pathways of neurodegeneration - multiple diseases

Gene Name：CHRM1

Protein Name：Muscarinic acetylcholine receptor M1

Human Gene Id：1128

Human Swiss Prot No：P11229

Mouse Gene Id：12669

Mouse Swiss Prot No：P12657

Rat Gene Id：25229

Rat Swiss Prot No：P08482

Immunogen：The antiserum was produced against synthesized peptide derived from human CHRM1. AA range:295-344

Specificity：mAChR M1 Polyclonal Antibody detects endogenous levels of mAChR M1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CHRM1;Muscarinic acetylcholine receptor M1

Observed Band(KD)：51kD

Background： The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008],

Function：function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with GPRASP2.,

Subcellular Location：Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Expression： Amygdala,Brain,