Target：Macroglobulin α-2

Fields：Complement and coagulation cascades

Gene Name：A2M

Protein Name：Alpha-2-macroglobulin

Human Gene Id：2

Human Swiss Prot No：P01023

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human A2M. AA range:871-920

Specificity：Macroglobulin α-2 Polyclonal Antibody detects endogenous levels of Macroglobulin α-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：A2M;CPAMD5;FWP007;Alpha-2-macroglobulin;Alpha-2-M;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5

Observed Band(KD)：170kD

Background： Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008],

Function：developmental stage:Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation.,function:Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.,online information:Alpha-2 macroglobulin entry,similarity:Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.,s

Subcellular Location：Secreted .

Expression：Secreted in plasma.