Target：Mad 4
Gene Name：MXD4
Protein Name：Max dimerization protein 4
Human Gene Id：10608
Human Swiss Prot No：Q14582
Mouse Swiss Prot No：Q60948
Immunogen：The antiserum was produced against synthesized peptide derived from human MAD4. AA range:10-59
Specificity：Mad 4 Polyclonal Antibody detects endogenous levels of Mad 4 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：MXD4;BHLHC12;MAD4;Max dimerization protein 4;Max dimerizer 4;Class C basic helix-loop-helix protein 12;bHLHc12;Max-associated protein 4;Max-interacting transcriptional repressor MAD4
Molecular Weight(Da)：24kD
Background： This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008],
Function：function:Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17.,
Subcellular Location：Nucleus .
Expression： Brain,Lung,Normal aorta,Spleen,
