Target：MAGI-2

Fields：Rap1 signaling pathway;PI3K-Akt signaling pathway

Gene Name：MAGI2

Protein Name：Membrane-associated guanylate kinase WW and PDZ domain-containing protein 2

Human Gene Id：9863

Human Swiss Prot No：Q86UL8

Mouse Gene Id：50791

Mouse Swiss Prot No：Q9WVQ1

Rat Gene Id：113970

Rat Swiss Prot No：O88382

Immunogen：The antiserum was produced against synthesized peptide derived from human MAGI2. AA range:221-270

Specificity：MAGI-2 Polyclonal Antibody detects endogenous levels of MAGI-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MAGI2;ACVRINP1;AIP1;KIAA0705;Membrane-associated guanylate kinase; WW and PDZ domain-containing protein 2;Atrophin-1-interacting protein 1;AIP-1;Atrophin-1-interacting protein A;Membrane-associated guanylate kinase inverted 2;MAGI-

Observed Band(KD)：156kD

Background： The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008],

Function：function:Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation.,similarity:Belongs to the MAGUK family.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 2 WW domains.,similarity:Contains 6 PDZ (DHR) domains.,subcellular location:Membrane-associated in synaptosomes.,subunit:Interacts via its WW domains with DRPLA. Interacts via its second PDZ domain with PTEN unphosphorylated C-terminus; this interaction diminishes the degradation rate of PTEN (By similarity). Interacts through its guanylate kinase domain with DLGAP1 (By similarity). Interacts through the PDZ domains with GRIN2A, GRID2 and NLGN1 (By similarity). Interacts with CTNND2, CTNNB1, MAGUIN-1, ACVR2A, SMAD2

Subcellular Location：Cytoplasm . Late endosome . Cell junction, synapse, synaptosome . Cell membrane ; Peripheral membrane protein . Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity). .

Expression：Specifically expressed in brain.