Target：MALT1

Fields：NF-kappa B signaling pathway;C-type lectin receptor signaling pathway;T cell receptor signaling pathway;B cell receptor signaling pathway;Shigellosis;Tuberculosis

Gene Name：MALT1

Protein Name：Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Human Gene Id：10892

Human Swiss Prot No：Q9UDY8

Mouse Gene Id：240354

Mouse Swiss Prot No：Q2TBA3

Immunogen：The antiserum was produced against synthesized peptide derived from human MALT1. AA range:301-350

Specificity：MALT1 Polyclonal Antibody detects endogenous levels of MALT1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MALT1;MLT;Mucosa-associated lymphoid tissue lymphoma translocation protein 1;MALT lymphoma-associated translocation;Paracaspase

Observed Band(KD)：90kD

Background： This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],

Function：disease:A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.,function:Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL-10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.,similarity:Belongs to the peptidase C14B family.,similarity:Contains 1 death domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.,subunit:Binds through its Ig-like

Subcellular Location：Cytoplasm, perinuclear region . Nucleus . Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10. .

Expression：Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.