Target：CD79b

Fields：B cell receptor signaling pathway

Gene Name：CD79B

Protein Name：B-cell antigen receptor complex-associated protein beta chain

Human Gene Id：974

Human Swiss Prot No：P40259

Mouse Swiss Prot No：P15530

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human CD79B. AA range:61-110

Specificity：CD79b Polyclonal Antibody detects endogenous levels of CD79b protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CD79B;B29;IGB;B-cell antigen receptor complex-associated protein beta chain;B-cell-specific glycoprotein B29;Ig-beta;Immunoglobulin-associated B29 protein;CD79b

Observed Band(KD)：37kD

Background： The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],

Function：disease:Defects in CD79B are a cause of non-Bruton type agammaglobulinemia [MIM:601495]. Agammaglobulinemia is an immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells.,function:Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.,online information:CD79B mutation db,PTM:Phosphorylated on tyrosine upon B-cell activation.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 1 ITAM domain.,subcellular location:Following antigen binding, the BCR has b

Subcellular Location：Cell membrane; Single-pass type I membrane protein. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. .

Expression：B-cells.