Target：CD70

Fields：Cytokine-cytokine receptor interaction

Gene Name：CD70 CD27L CD27LG TNFSF7

Protein Name：CD70 antigen (CD27 ligand) (CD27-L) (Tumor necrosis factor ligand superfamily member 7) (CD antigen CD70)

Human Gene Id：970

Human Swiss Prot No：P32970

Mouse Gene Id：21948

Mouse Swiss Prot No：O55237

Immunogen：Synthetic peptide from human protein at AA range: 150-193

Specificity：The antibody detects endogenous CD70

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CD70 antigen (CD27 ligand;CD27-L;Tumor necrosis factor ligand superfamily member 7;CD antigen CD70)

Background： The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008],

Function：function:Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,

Subcellular Location：Membrane ; Single-pass type II membrane protein .

Expression： B-cell,Kidney,