Target：CD42d
Fields：ECM-receptor interaction;Platelet activation;Hematopoietic cell lineage
Gene Name：GP5
Protein Name：Platelet glycoprotein V
Human Gene Id：2814
Human Swiss Prot No：P40197
Mouse Swiss Prot No：O08742
Rat Gene Id：25259
Rat Swiss Prot No：O08770
Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human GP5. AA range:331-380
Specificity：CD42d Polyclonal Antibody detects endogenous levels of CD42d protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：GP5;Platelet glycoprotein V;GPV;Glycoprotein 5;CD42d
Observed Band(KD)：62kD
Background： Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010],
Function：function:The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.,PTM:The N-terminus is blocked.,similarity:Contains 14 LRR (leucine-rich) repeats.,tissue specificity:Platelets and megakaryocytes.,
Subcellular Location：Membrane; Single-pass type I membrane protein.
Expression：Platelets and megakaryocytes.
