Target：CD3E

Fields：Hematopoietic cell lineage;Th1 and Th2 cell differentiation;Th17 cell differentiation;T cell receptor signaling pathway;Chagas disease;Measles;Human T-cell leukemia virus 1 infection;Epstein-Barr virus infection;Human immunodeficiency virus 1 infection;PD-L1 expression and PD-1 checkpoint pathway in cancer;Primary immunodeficiency

Gene Name：CD3E

Protein Name：T-cell surface glycoprotein CD3 epsilon chain

Human Gene Id：916

Human Swiss Prot No：P07766

Mouse Swiss Prot No：P22646

Immunogen：The antiserum was produced against synthesized peptide derived from human CD3-epsilon. AA range:22-71

Specificity：CD3-ε Polyclonal Antibody detects endogenous levels of CD3-ε protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CD3E;T3E;T-cell surface glycoprotein CD3 epsilon chain;T-cell surface antigen T3/Leu-4 epsilon chain;CD antigen CD3e

Observed Band(KD)：21kD

Background： The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008],

Function：function:The CD3 complex mediates signal transduction.,online information:CD3E mutation db,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,similarity:Contains 1 ITAM domain.,subunit:The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein .

Expression： Blood,T-cell,