Target：CD3G

Fields：Hematopoietic cell lineage;Th1 and Th2 cell differentiation;Th17 cell differentiation;T cell receptor signaling pathway;Chagas disease;Measles;Human T-cell leukemia virus 1 infection;Epstein-Barr virus infection;Human immunodeficiency virus 1 infection;PD-L1 expression and PD-1 checkpoint pathway in cancer

Gene Name：CD3G T3G

Protein Name：T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)

Human Gene Id：917

Human Swiss Prot No：P09693

Mouse Swiss Prot No：P11942

Rat Swiss Prot No：Q64159

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：CD3G Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：20kD

Background： The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008],

Function：domain:A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes.,function:The CD3 complex mediates signal transduction.,online information:CD3 receptor entry,online information:CD3G mutation db,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,similarity:Contains 1 ITAM domain.,subunit:The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein.

Expression： T-cell,Thymus,