Target：CD38

Fields：Nicotinate and nicotinamide metabolism;Metabolic pathways;Calcium signaling pathway;Hematopoietic cell lineage;Oxytocin signaling pathway;Salivary secretion;Pancreatic secretion

Gene Name：CD38

Protein Name：ADP-ribosyl cyclase 1

Human Gene Id：952

Human Swiss Prot No：P28907

Mouse Swiss Prot No：P56528

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human CD38. AA range:211-260

Specificity：CD38 Polyclonal Antibody detects endogenous levels of CD38 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CD38;ADP-ribosyl cyclase 1;Cyclic ADP-ribose hydrolase 1;cADPr hydrolase 1;T10;CD38

Observed Band(KD)：35kD

Background： The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],

Function：catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,developmental stage:Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.,enzyme regulation:ATP inhibits the hydrolyzing activity.,function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.,online information:CD38 entry,similarity:Belongs to the ADP-ribosyl cyclase family.,tissue specificity:Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.,

Subcellular Location：Membrane; Single-pass type II membrane protein.

Expression：Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.