Target：CD34

Fields：Cell adhesion molecules;Hematopoietic cell lineage

Gene Name：CD34

Protein Name：Hematopoietic progenitor cell antigen CD34

Human Gene Id：947

Human Swiss Prot No：P28906

Mouse Gene Id：12490

Mouse Swiss Prot No：Q64314

Immunogen：The antiserum was produced against synthesized peptide derived from human CD34. AA range:208-257

Specificity：CD34 Polyclonal Antibody detects endogenous levels of CD34 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:100-500;IF ICC 1:100-500;ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CD34;Hematopoietic progenitor cell antigen CD34;CD antigen CD34

Observed Band(KD)：110kD

Background： The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],

Function：alternative products:Both isoforms are expressed on the cell surface. CD34-T/CD34-F ratio increases with cell differentiation,developmental stage:On early hematopoietic progenitor cells.,disease:Abnormal CD34 expression in leukemogenesis.,function:Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.,online information:CD34 entry,PTM:Highly glycosylated.,PTM:Phosphorylated on serine residues by PKC.,similarity:Belongs to the CD34 family.,tissue specificity:Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tiss

Subcellular Location：Membrane; Single-pass type I membrane protein.

Expression：Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.