Target：CD32

Fields：Phagosome;Osteoclast differentiation;B cell receptor signaling pathway;Fc gamma R-mediated phagocytosis;Staphylococcus aureus infection;Tuberculosis;Measles

Gene Name：FCGR2B/FCGR2C

Protein Name：Low affinity immunoglobulin gamma Fc region receptor II-b/Low affinity immunoglobulin gamma Fc region receptor II-c

Human Gene Id：2213

Human Swiss Prot No：P31994

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human FCGR2B/C. AA range:141-190

Specificity：CD32-B/C Polyclonal Antibody detects endogenous levels of CD32-B/C protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：FCGR2B;CD32;FCG2;IGFR2;Low affinity immunoglobulin gamma Fc region receptor II-b;IgG Fc receptor II-b;CDw32;Fc-gamma RII-b;Fc-gamma-RIIb;FcRII-b;CD32;FCGR2C;CD32;FCG2;IGFR2;Low affinity immunoglobulin gamma Fc region receptor II-c;IgG Fc receptor II-c;CDw32;Fc-gamma RII-c;Fc-gamma-RIIc;FcRII-c;CD32

Observed Band(KD)：35kD

Background：Low affinity immunoglobulin gamma Fc region receptor II-b/Low affinity immunoglobulin gamma Fc region receptor II-c encoded by FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.

Function：immune response,

Subcellular Location：Cell membrane; Single-pass type I membrane protein.

Expression：Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.