Target：CD27

Fields：Cytokine-cytokine receptor interaction

Gene Name：CD27 TNFRSF7

Protein Name：CD27 antigen (CD27L receptor) (T-cell activation antigen CD27) (T14) (Tumor necrosis factor receptor superfamily member 7) (CD antigen CD27)

Human Gene Id：939

Human Swiss Prot No：P26842

Mouse Swiss Prot No：P41272

Immunogen：Synthesized peptide derived from human protein . at AA range: 1-80

Specificity：CD27 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：28kD

Background： The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008],

Function：function:Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.,PTM:Phosphorylated and O-glycosylated.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Homodimer. Interacts with SIVA1 and TRAF2.,tissue specificity:Found in most T-lymphocytes.,

Subcellular Location：Membrane; Single-pass type I membrane protein.

Expression：Found in most T-lymphocytes.