Target：CD249

Fields：Renin-angiotensin system

Gene Name：ENPEP

Protein Name：Glutamyl aminopeptidase

Human Gene Id：2028

Human Swiss Prot No：Q07075

Mouse Gene Id：13809

Mouse Swiss Prot No：P16406

Rat Gene Id：64017

Rat Swiss Prot No：P50123

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human ENPEP. AA range:671-720

Specificity：CD249 Polyclonal Antibody detects endogenous levels of CD249 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ENPEP;Glutamyl aminopeptidase;EAP;Aminopeptidase A;AP-A;Differentiation antigen gp160;CD249

Observed Band(KD)：110kD

Background：catalytic activity:Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide.,cofactor:Binds 1 zinc ion per subunit.,function:Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.,similarity:Belongs to the peptidase M1 family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues.,

Function：catalytic activity:Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide.,cofactor:Binds 1 zinc ion per subunit.,function:Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.,similarity:Belongs to the peptidase M1 family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues.,

Subcellular Location：Cell membrane ; Single-pass type II membrane protein.

Expression：Expressed in choriocarcinoma cancer cell lines (at protein level) (PubMed:10692253). Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues.