Target：GNA11

Fields：Calcium signaling pathway;cGMP-PKG signaling pathway;Vascular smooth muscle contraction;Gap junction;Cholinergic synapse;Long-term depression;Insulin secretion;GnRH signaling pathway;Aldosterone synthesis and secretion;Cortisol synthesis and secretion;Parathyroid hormone synthesis, secretion and action;GnRH secretion;Cushing syndrome;Growth hormone synthesis, secretion and action;Chagas disease;Amoebiasis;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Pathways in cancer

Gene Name：GNA11 GA11

Protein Name：Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (Guanine nucleotide-binding protein G(y) subunit alpha)

Human Gene Id：2767

Human Swiss Prot No：P29992

Mouse Swiss Prot No：P21278

Rat Swiss Prot No：Q9JID2

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：GNA11 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：39kD

Background： The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013],

Function：function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.,similarity:Belongs to the G-alpha family. G(q) subfamily.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.,

Subcellular Location：Cell membrane ; Lipid-anchor . Cytoplasm . In testicular cells, expressed exclusively in the cytoplasm.

Expression：Expressed in testis.