Target：CD232

Fields：Axon guidance

Gene Name：PLXNC1

Protein Name：Plexin-C1

Human Gene Id：10154

Human Swiss Prot No：O60486

Mouse Gene Id：54712

Mouse Swiss Prot No：Q9QZC2

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human PLXNC1. AA range:811-860

Specificity：CD232 Polyclonal Antibody detects endogenous levels of CD232 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PLXNC1;VESPR;Plexin-C1;Virus-encoded semaphorin protein receptor;CD232

Observed Band(KD)：175kD

Background： This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011],

Function：function:Receptor for vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of viral semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8.,PTM:N-glycosylated.,similarity:Belongs to the plexin family.,similarity:Contains 1 Sema domain.,tissue specificity:Detected in heart, brain, lung, spleen and placenta.,

Subcellular Location：Membrane ; Single-pass type I membrane protein .

Expression：Detected in heart, brain, lung, spleen and placenta.