Target：CD223

Gene Name：LAG3

Protein Name：Lymphocyte activation gene 3 protein

Human Gene Id：3902

Human Swiss Prot No：P18627

Mouse Gene Id：16768

Mouse Swiss Prot No：Q61790

Rat Gene Id：297596

Rat Swiss Prot No：Q5BK54

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human LAG3. AA range:91-140

Specificity：CD223 Polyclonal Antibody detects endogenous levels of CD223 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：LAG3;FDC;Lymphocyte activation gene 3 protein;LAG-3;Protein FDC;CD223

Observed Band(KD)：57kD

Background： Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008],

Function：function:Involved in lymphocyte activation. Binds to HLA class-II antigens.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:On cell surface of activated NK and T-lymphocytes.,

Subcellular Location：[Lymphocyte activation gene 3 protein]: Cell membrane ; Single-pass type I membrane protein .; [Secreted lymphocyte activation gene 3 protein]: Secreted . Produced following cleavage of the main chain. .

Expression：Primarily expressed in activated T-cells and a subset of natural killer (NK) cells.