Target：CD168

Fields：ECM-receptor interaction

Gene Name：HMMR IHABP RHAMM

Protein Name：Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168)

Human Gene Id：3161

Human Swiss Prot No：O75330

Mouse Gene Id：15366

Mouse Swiss Prot No：Q00547

Immunogen：Synthetic peptide from human protein at AA range: 280-340

Specificity：The antibody detects endogenous CD168

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000,IHC 1:500-200, ELISA 1:10000-20000. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein;Receptor for hyaluronan-mediated motility;CD antigen CD168)

Observed Band(KD)：84kD

Background： The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008],

Function：function:Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.,subunit:Subunit of the HARC complex.,tissue specificity:Expressed in breast cancer cell lines and in normal breast tissue.,

Subcellular Location：Cell surface . Cytoplasm . Cytoplasm, cytoskeleton, spindle .

Expression：Expressed in testis (PubMed:22965910). Expressed in the breast (PubMed:8890751).