Target：CD158z

Fields：Antigen processing and presentation;Natural killer cell mediated cytotoxicity;Graft-versus-host disease

Gene Name：KIR3DL3

Protein Name：Killer cell immunoglobulin-like receptor 3DL3

Human Gene Id：100133046

Human Swiss Prot No：Q8N743

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human KIR3DL3. AA range:231-280

Specificity：CD158z Polyclonal Antibody detects endogenous levels of CD158z protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：KIR3DL3;CD158Z;KIR3DL7;KIRC1;Killer cell immunoglobulin-like receptor 3DL3;CD158 antigen-like family member Z;Killer cell inhibitory receptor 1;CD158z

Observed Band(KD)：45kD

Background：killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3(KIR3DL3) Homo sapiens Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the

Function：function:Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.,similarity:Belongs to the immunoglobulin superfamily.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,

Subcellular Location：Cell membrane; Single-pass type I membrane protein.

Expression： Peripheral blood,