Target：CD116

Fields：Cytokine-cytokine receptor interaction;JAK-STAT signaling pathway;Hematopoietic cell lineage;Pathways in cancer

Gene Name：CSF2RA

Protein Name：Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Human Gene Id：1438

Human Swiss Prot No：P15509

Mouse Swiss Prot No：Q00941

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human CSF2RA. AA range:121-170

Specificity：CD116 Polyclonal Antibody detects endogenous levels of CD116 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CSF2RA;CSF2R;CSF2RY;Granulocyte-macrophage colony-stimulating factor receptor subunit alpha;GM-CSF-R-alpha;GMCSFR-alpha;GMR-alpha;CDw116;CD116

Observed Band(KD)：44kD

Background： The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008],

Function：domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.,miscellaneous:The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.,similarity:Belongs to the type I cytokine receptor family. Type 5 subfamily.,subunit:Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.,

Subcellular Location：Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted .; [Isoform 4]: Secreted .; [Isoform 6]: Secreted .

Expression： Blood,Placenta,Synovial membrane tissue,Uterus,