Target：CCRL1

Fields：Cytokine-cytokine receptor interaction;Viral protein interaction with cytokine and cytokine receptor

Gene Name：CCRL1

Protein Name：C-C chemokine receptor type 11

Human Gene Id：51554

Human Swiss Prot No：Q9NPB9

Mouse Gene Id：252837

Mouse Swiss Prot No：Q924I3

Immunogen：The antiserum was produced against synthesized peptide derived from human CCRL1. AA range:291-340

Specificity：CCRL1 Polyclonal Antibody detects endogenous levels of CCRL1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CCRL1;CCBP2;CCR11;VSHK1;C-C chemokine receptor type 11;C-C CKR-11;CC-CKR-11;CCR-11;CC chemokine receptor-like 1;CCRL1;CCX CKR

Observed Band(KD)：40kD

Background： The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013],

Function：function:Receptor for CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine.,

Subcellular Location：Early endosome . Recycling endosome . Cell membrane ; Multi-pass membrane protein . Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.

Expression：Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine.