Target：CCNG2

Fields：FoxO signaling pathway;p53 signaling pathway

Gene Name：CCNG2

Protein Name：Cyclin-G2

Human Gene Id：901

Human Swiss Prot No：Q16589

Mouse Swiss Prot No：O08918

Immunogen：Synthesized peptide derived from human protein . at AA range: 20-100

Specificity：CCNG2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：37kD

Background： The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008],

Function：developmental stage:Expression levels increase through the cell cycle to peak in the mid/late-S phase and decrease during G2/M phase.,function:May play a role in growth regulation and in negative regulation of cell cycle progesssion.,induction:Activated by actinomycin-D induced DNA damage.,similarity:Belongs to the cyclin family.,similarity:Belongs to the cyclin family. Cyclin G subfamily.,tissue specificity:High levels in cerebellum, thymus, spleen and prostate. Low levels in skeletal muscle.,

Subcellular Location：Cytoplasm .

Expression：High levels in cerebellum, thymus, spleen and prostate. Low levels in skeletal muscle.