Target：CCNB2

Fields：FoxO signaling pathway;Cell cycle;Oocyte meiosis;p53 signaling pathway;Cellular senescence;Progesterone-mediated oocyte maturation;Human T-cell leukemia virus 1 infection;Human immunodeficiency virus 1 infection

Gene Name：CCNB2

Protein Name：G2/mitotic-specific cyclin-B2

Human Gene Id：9133

Human Swiss Prot No：O95067

Mouse Swiss Prot No：P30276

Immunogen：Synthesized peptide derived from human protein . at AA range: 60-140

Specificity：CCNB2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：43kD

Background： Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008],

Function：developmental stage:Accumulates steadily during G2 and is abruptly destroyed at mitosis.,function:Essential for the control of the cell cycle at the G2/M (mitosis) transition.,similarity:Belongs to the cyclin family.,similarity:Belongs to the cyclin family. Cyclin AB subfamily.,subunit:Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.,

Subcellular Location：nucleus,nucleoplasm,centrosome,cytosol,cell-cell adherens junction,microtubule cytoskeleton,membrane,

Expression： Brain,Coronary artery,Testis,