Target：CCDC8

Gene Name：CCDC8

Protein Name：Coiled-coil domain-containing protein 8

Human Gene Id：83987

Human Swiss Prot No：Q9H0W5

Mouse Swiss Prot No：D3YZV8

Rat Swiss Prot No：P62521

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：CCDC8 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：59kD

Background： This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a cofactor required for p53-mediated apoptosis following DNA damage, and may also play a role in growth through interactions with the cytoskeletal adaptor protein obscurin-like 1. Mutations in this gene are a cause of 3M syndrome-3 (3M3). [provided by RefSeq, Dec 2011],

Function：PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,

Subcellular Location：Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .

Expression：Widely expressed with low levels in spleen, skeletal muscle, small intestine, kidney and liver.