Target：CBPA4

Gene Name：CPA4 CPA3 UNQ694/PRO1339

Protein Name：Carboxypeptidase A4 (EC 3.4.17.-) (Carboxypeptidase A3)

Human Gene Id：51200

Human Swiss Prot No：Q9UI42

Mouse Swiss Prot No：Q6P8K8

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：CBPA4 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：46kD

Background： This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008],

Function：cofactor:Binds 1 zinc ion per subunit.,function:Metalloprotease that could be involved in the histone hyperacetylation pathway.,induction:Up-regulated by inhibitors of histone dacetylation.,similarity:Belongs to the peptidase M14 family.,subunit:Interacts with LXN.,tissue specificity:Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele.,

Subcellular Location：Secreted .

Expression：Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele.