Target：MAP-2

Gene Name：MAP2

Protein Name：Microtubule-associated protein 2

Human Gene Id：4133

Human Swiss Prot No：P11137

Mouse Swiss Prot No：P20357

Rat Swiss Prot No：P15146

Immunogen：The antiserum was produced against synthesized peptide derived from human MAP-2. AA range:14-63

Specificity：MAP-2 Polyclonal Antibody detects endogenous levels of MAP-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MAP2;Microtubule-associated protein 2;MAP-2

Observed Band(KD)：280kD

Background： This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010],

Function：alternative products:Additional isoforms seem to exist,function:The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.,PTM:MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 3 Tau/MAP repeats.,similarity:Contains 4 Tau/MAP repeats.,

Subcellular Location：Cytoplasm, cytoskeleton . Cell projection, dendrite .

Expression： Brain,Brain cortex,Epithelium,Pancreas,Testis,