Target：MARCO

Fields：Phagosome

Gene Name：MARCO SCARA2

Protein Name：Macrophage receptor MARCO (Macrophage receptor with collagenous structure) (Scavenger receptor class A member 2)

Human Gene Id：8685

Human Swiss Prot No：Q9UEW3

Mouse Swiss Prot No：Q60754

Immunogen：Synthesized peptide derived from human protein . at AA range: 380-460

Specificity：MARCO Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：57kD

Background： The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008],

Function：function:Binds Gram-positive and Gram-negative bacteria.,similarity:Contains 1 collagen-like domain.,similarity:Contains 1 SRCR domain.,

Subcellular Location：Cell membrane ; Single-pass type II membrane protein .

Expression：Expressed in alveolar macrophages (at protein level). Detected in macrophages from various tissues including thymus, kidney, Kupffer cells of liver, and spleen (PubMed:9468508).