Target：MARH6

Fields：Protein processing in endoplasmic reticulum

Gene Name：MARCH6 KIAA0597 RNF176 TEB4

Protein Name：E3 ubiquitin-protein ligase MARCH6 (EC 6.3.2.-) (Doa10 homolog) (Membrane-associated RING finger protein 6) (Membrane-associated RING-CH protein VI) (MARCH-VI) (Protein TEB-4) (RING finger protein 176

Human Gene Id：10299

Human Swiss Prot No：O60337

Mouse Swiss Prot No：Q6ZQ89

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：MARH6 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：100kD

Background： This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012],

Function：domain:The RING-CH-type zinc finger domain is required for E3 ligase activity.,function:E3 ubiquitin-protein ligase. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,PTM:Auto-ubiquitinated, which results in proteasomal degradation.,similarity:Contains 1 RING-CH-type zinc finger.,tissue specificity:Present in brain (at protein level).,

Subcellular Location：Endoplasmic reticulum membrane ; Multi-pass membrane protein .

Expression：Present in brain (at protein level).