Target：CATS

Fields：Lysosome;Phagosome;Apoptosis;Antigen processing and presentation;Tuberculosis

Gene Name：CTSS

Protein Name：Cathepsin S (EC 3.4.22.27)

Human Gene Id：1520

Human Swiss Prot No：P25774

Mouse Swiss Prot No：O70370

Rat Swiss Prot No：Q02765

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：CATS Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：36kD

Background： The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010],

Function：catalytic activity:Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.,function:Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.,similarity:Belongs to the peptidase C1 family.,subunit:Monomer.,

Subcellular Location：Lysosome . Secreted . Cytoplasmic vesicle, phagosome .

Expression： Alveolar macrophage,Pancreas,Testis,