Target：MATR3

Fields：Amyotrophic lateral sclerosis

Gene Name：MATR3 KIAA0723

Protein Name：Matrin-3

Human Gene Id：9782

Human Swiss Prot No：P43243

Mouse Swiss Prot No：Q8K310

Rat Swiss Prot No：P43244

Immunogen：Synthesized peptide derived from part region of human protein AA range: 181-231

Specificity：MATR3 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：93kD

Background：matrin 3(MATR3) Homo sapiens This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X. [provided by RefSeq, Aug 2013],

Function：function:May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs.,similarity:Contains 1 matrin-type zinc finger.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subunit:Part of complex consisting of SFPQ, NONO and MATR3.,

Subcellular Location：Nucleus matrix.

Expression： Amygdala,Brain,Epithelium,Fetal kidney,Hypothalamus,Liver,Retina,Skin,