Target：Cardiotrophin-1

Fields：Cytokine-cytokine receptor interaction;JAK-STAT signaling pathway

Gene Name：CTF1

Protein Name：Cardiotrophin-1

Human Gene Id：1489

Human Swiss Prot No：Q16619

Mouse Gene Id：13019

Mouse Swiss Prot No：Q60753

Immunogen：Synthesized peptide derived from human Cardiotrophin-1. at AA range: 151-200

Specificity：This antibody detects endogenous levels of Cardiotrophin-1

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000, ELISA 1:10000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Cardiotrophin-1 (CT-1)

Observed Band(KD)：23kD

Background： The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008],

Function：function:Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.,similarity:Belongs to the IL-6 superfamily.,tissue specificity:Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.,

Subcellular Location：Secreted.

Expression：Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.