Target：CAN6
Gene Name：CAPN6 CALPM CANPX
Protein Name：Calpain-6 (Calpain-like protease X-linked) (Calpamodulin) (CalpM)
Human Gene Id：827
Human Swiss Prot No：Q9Y6Q1
Mouse Swiss Prot No：O35646
Rat Swiss Prot No：O88501
Immunogen：Synthesized peptide derived from part region of human protein
Specificity：CAN6 Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：70kD
Background： Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009],
Function：function:Not known; does not seem to have protease activity as it has lost the active site residues.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 C2 domain.,similarity:Contains 1 calpain catalytic domain.,tissue specificity:Expressed only in placenta.,
Subcellular Location：Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton, spindle . During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle.
Expression：Expressed only in placenta.
