Target：Calpain 11

Gene Name：CAPN11

Protein Name：Calpain-11

Human Gene Id：11131

Human Swiss Prot No：Q9UMQ6

Mouse Swiss Prot No：Q6J756

Immunogen：The antiserum was produced against synthesized peptide derived from human CAPN11. AA range:401-450

Specificity：Calpain 11 Polyclonal Antibody detects endogenous levels of Calpain 11 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CAPN11;Calpain-11;Calcium-activated neutral proteinase 11;CANP 11

Observed Band(KD)：81kD

Background： Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008],

Function：catalytic activity:Broad endopeptidase specificity.,function:Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 calpain catalytic domain.,similarity:Contains 2 EF-hand domains.,subunit:Heterodimer of a large (catalytic) and a small (regulatory) subunit.,tissue specificity:Highest expression in testis.,

Subcellular Location：Cytoplasmic vesicle, secretory vesicle, acrosome .

Expression：Highest expression in testis.