Target：CAF-1 p150

Gene Name：CHAF1A

Protein Name：Chromatin assembly factor 1 subunit A

Human Gene Id：10036

Human Swiss Prot No：Q13111

Mouse Gene Id：27221

Mouse Swiss Prot No：Q9QWF0

Immunogen：Synthesized peptide derived from CAF-1 p150 . at AA range: 300-380

Specificity：CAF-1 p150 Polyclonal Antibody detects endogenous levels of CAF-1 p150 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CHAF1A;CAF;CAF1P150;Chromatin assembly factor 1 subunit A;CAF-1 subunit A;Chromatin assembly factor I p150 subunit;CAF-I 150 kDa subunit;CAF-I p150;hp150

Observed Band(KD)：150kD

Background： Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008],

Function：alternative products:Experimental confirmation may be lacking for some isoforms,developmental stage:Active complex is found in G1, S and G2 phases.,domain:Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.,function:Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenanc

Subcellular Location：Nucleus . DNA replication foci.

Expression： Brain,Cervix adenocarcinoma,Epithelium,Ovary,