Target：CacyBP

Fields：Wnt signaling pathway

Gene Name：CACYBP

Protein Name：Calcyclin-binding protein

Human Gene Id：27101

Human Swiss Prot No：Q9HB71

Mouse Gene Id：12301

Mouse Swiss Prot No：Q9CXW3

Rat Gene Id：289144

Rat Swiss Prot No：Q6AYK6

Immunogen：The antiserum was produced against synthesized peptide derived from the C-terminal region of human CACYBP. AA range:171-220

Specificity：CacyBP Polyclonal Antibody detects endogenous levels of CacyBP protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CACYBP;S100A6BP;SIP;PNAS-107;Calcyclin-binding protein;CacyBP;hCacyBP;S100A6-binding protein;Siah-interacting protein

Observed Band(KD)：25kD

Background： The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Function：function:May be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).,PTM:Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.,similarity:Contains 1 CS domain.,similarity:Contains 1 SGS domain.,subcellular location:Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.,subunit:Interacts with protein of the S100 family S100A1, S100A6, S100B, S100P and S100A12 at physiological calcium concentrations (By similarity). Component of some large E3 complex at least composed of UBE2D1, SIAH1, CAC

Subcellular Location：Nucleus . Cytoplasm . Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.

Expression： Brain,Colon carcinoma,Hepatoma,Liver,Promyelocytic leukemia,Skeletal muscle