Target：CAC1S

Fields：MAPK signaling pathway;Calcium signaling pathway;cGMP-PKG signaling pathway;cAMP signaling pathway;Cardiac muscle contraction;Adrenergic signaling in cardiomyocytes;Vascular smooth muscle contraction;Retrograde endocannabinoid signaling;Cholinergic synapse;Serotonergic synapse;GABAergic synapse;Insulin secretion;GnRH signaling pathway;Oxytocin signaling pathway;Renin secretion;Aldosterone synthesis and secretion;Cortisol synthesis and secretion;GnRH secretion;Cushing syndrome;Growth hormone synthesis, secretion and action;Alzheimer disease;Prion disease;Pathways of neurodegeneration - multiple diseases;Chemical carcinogenesis - receptor activation;Hypertrophic cardiomyopathy;Arrhythmogenic right ventricular cardiomyopathy;Dilated cardiomyopathy

Gene Name：CACNA1S CACH1 CACN1 CACNL1A3

Protein Name：Voltage-dependent L-type calcium channel subunit alpha-1S (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle) (Voltage-gated calcium channel subunit alpha Cav1.1)

Human Gene Id：779

Human Swiss Prot No：Q13698

Mouse Swiss Prot No：Q02789

Rat Swiss Prot No：Q02485

Immunogen：Synthesized peptide derived from human protein . at AA range: 330-410

Specificity：CAC1S Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：206kD

Background：calcium voltage-gated channel subunit alpha1 S(CACNA1S) Homo sapiens This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. [provided by RefSeq, Jul 2008],

Function：disease:Defects in CACNA1S are a cause of periodic paralysis hypokalemic (HOKPP) [MIM:170400]; also designated HYPOPP. HOKPP is an autosomal dominant disorder manifested by episodic flaccid generalized muscle weakness associated with falls of serum potassium levels.,disease:Defects in CACNA1S are the cause of malignant hyperthermia susceptibility 5 (MHS5) [MIM:601887]; an autosomal dominant disorder that is potentially lethal in susceptible individuals on exposure to commonly used inhalational anesthetics and depolarizing muscle relaxants.,domain:Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.,domain:The loop between repeats II and III in

Subcellular Location：Cell membrane, sarcolemma, T-tubule ; Multi-pass membrane protein .

Expression：Skeletal muscle specific.