Target：CA XIV

Fields：Nitrogen metabolism;Metabolic pathways

Gene Name：CA14

Protein Name：Carbonic anhydrase 14

Human Gene Id：23632

Human Swiss Prot No：Q9ULX7

Mouse Gene Id：23831

Mouse Swiss Prot No：Q9WVT6

Immunogen：The antiserum was produced against synthesized peptide derived from human CA14. AA range:161-210

Specificity：CA XIV Polyclonal Antibody detects endogenous levels of CA XIV protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CA14;Carbonic anhydrase 14;Carbonate dehydratase XIV;Carbonic anhydrase XIV;CA-XIV

Observed Band(KD)：34kD

Background： Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008],

Function：catalytic activity:H(2)CO(3) = CO(2) + H(2)O.,cofactor:Zinc.,function:Reversible hydration of carbon dioxide.,similarity:Belongs to the alpha-carbonic anhydrase family.,tissue specificity:High expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle.,

Subcellular Location：Membrane ; Single-pass type I membrane protein .

Expression：High expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle.