Target：C5ARL

Gene Name：GPR77 C5L2

Protein Name：C5a anaphylatoxin chemotactic receptor C5L2 (G-protein coupled receptor 77)

Human Gene Id：27202

Human Swiss Prot No：Q9P296

Mouse Swiss Prot No：Q8BW93

Rat Swiss Prot No：Q695P6

Immunogen：Synthesized peptide derived from human protein . at AA range: 270-350

Specificity：C5ARL Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：37kD

Background： This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012],

Function：function:Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, C4a and C3a and their desarginated derivatives. Couples weakly to Gi-mediated signaling pathways.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Frontal cortex, hippocampus, hypothalamus, pons and liver.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Frontal cortex, hippocampus, hypothalamus, pons and liver.