Target：C3aR

Fields：Neuroactive ligand-receptor interaction;Complement and coagulation cascades;Alcoholic liver disease;Staphylococcus aureus infection;Coronavirus disease - COVID-19

Gene Name：C3AR1

Protein Name：C3a anaphylatoxin chemotactic receptor

Human Gene Id：719

Human Swiss Prot No：Q16581

Mouse Swiss Prot No：O09047

Immunogen：The antiserum was produced against synthesized peptide derived from human C3AR1. AA range:175-224

Specificity：C3aR Polyclonal Antibody detects endogenous levels of C3aR protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：C3AR1;AZ3B;C3R1;HNFAG09;C3a anaphylatoxin chemotactic receptor;C3AR;C3a-R

Molecular Weight(Da)：54kD

Background： C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. [provided by RefSeq, May 2016],

Function：function:Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.,PTM:Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues.