Target：C1QA

Fields：Complement and coagulation cascades;Alcoholic liver disease;Prion disease;Pertussis;Chagas disease;Staphylococcus aureus infection;Coronavirus disease - COVID-19;Systemic lupus erythematosus

Gene Name：C1QA

Protein Name：Complement C1q subcomponent subunit A

Human Gene Id：712

Human Swiss Prot No：P02745

Mouse Swiss Prot No：P98086

Rat Swiss Prot No：P31720

Immunogen：Synthesized peptide derived from part region of human protein AA range: 181-230

Specificity：C1QA Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 IHC 1:50-200 ELISA 1:5000-20000. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：26kD

Background： This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008],

Function：disease:Defects in C1QA are a cause of C1q deficiency [MIM:120550]. It is a rare genetic disorder which is associated with recurrent infections and a high prevalence of lupus erythematosus-like symptoms. It is characterized by a loss of activation of the complement classical pathway.,function:C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.,online information:C1QA mutation db,PTM:O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.,similarity:Contains 1 C1q domain.,similarity:Contains 1 collagen-like dom

Subcellular Location：Secreted.

Expression： Liver,Monocyte,Plasma,Spleen,