Target：BST-1
Fields：Nicotinate and nicotinamide metabolism;Metabolic pathways;Salivary secretion;Pancreatic secretion
Gene Name：BST1
Protein Name：ADP-ribosyl cyclase 2
Human Gene Id：683
Human Swiss Prot No：Q10588
Mouse Gene Id：12182
Mouse Swiss Prot No：Q64277
Rat Gene Id：81506
Rat Swiss Prot No：Q63072
Immunogen：The antiserum was produced against synthesized peptide derived from human BST1. AA range:71-120
Specificity：BST-1 Polyclonal Antibody detects endogenous levels of BST-1 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：BST1;ADP-ribosyl cyclase 2;Bone marrow stromal antigen 1;BST-1;Cyclic ADP-ribose hydrolase 2;cADPr hydrolase 2;CD antigen CD157
Observed Band(KD)：34kD
Background： Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008],
Function：catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,disease:Rheumatoid arthritis (RA) patients show enhanced expression of BST-1 transcripts in bone marrow stromal cell lines. This suggests that BST-1 overexpression may play a role in B-cell abnormalities in RA.,function:Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.,similarity:Belongs to the ADP-ribosyl cyclase family.,subunit:Homodimer.,tissue specificity:Widely expressed.,
Subcellular Location：Cell membrane; Lipid-anchor, GPI-anchor.
Expression：Widely expressed.
