Target：BRE

Fields：Homologous recombination

Gene Name：BRE

Protein Name：BRCA1-A complex subunit BRE

Human Gene Id：9577

Human Swiss Prot No：Q9NXR7

Mouse Gene Id：107976

Mouse Swiss Prot No：Q8K3W0

Rat Gene Id：362704

Rat Swiss Prot No：Q6P7Q1

Immunogen：The antiserum was produced against synthesized peptide derived from human BRE. AA range:325-374

Specificity：BRE Polyclonal Antibody detects endogenous levels of BRE protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：BRE;BRCC45;BRCA1-A complex subunit BRE;BRCA1/BRCA2-containing complex subunit 45;Brain and reproductive organ-expressed protein

Observed Band(KD)：47kD

Background： This gene encodes an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. The encoded protein acts as an adapter in several protein complexes, including the BRCA1-A complex and the BRISC complex. The BRCA1-A complex possesses ubiquitinase activity and targets sites of double strand DNA breaks, while the BRISC complex exhibits deubiquitinase activity and is involved in mitotic spindle assembly. This gene is upregulated in several types of cancer. [provided by RefSeq, Jun 2016],

Function：alternative products:Additional isoforms may exist,domain:Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.,function:Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between MERIT40/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probabl

Subcellular Location：Cytoplasm . Nucleus . Localizes at sites of DNA damage at double-strand breaks (DSBs). .

Expression：Expressed in all cell lines examined. Highly expressed in placenta.