Target：BNIP-3

Fields：FoxO signaling pathway;Mitophagy - animal;Autophagy - animal;Shigellosis;Legionellosis

Gene Name：BNIP3

Protein Name：BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Human Gene Id：664

Human Swiss Prot No：Q12983

Mouse Swiss Prot No：O55003

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human BNIP3. AA range:71-120

Specificity：BNIP-3 Polyclonal Antibody detects endogenous levels of BNIP-3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：BNIP3;NIP3;BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Observed Band(KD)：22kD

Background： This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014],

Function：function:Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2.,similarity:Belongs to the NIP3 family.,subcellular location:Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope.,subunit:Homodimer. Binds to BCL2. Interacts with BNIP3L. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1.,

Subcellular Location：Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane.

Expression： B-cell,Brain,Cerebellum,Kidney,Testis,