Target：Bcl-7a

Gene Name：BCL7A

Protein Name：B-cell CLL/lymphoma 7 protein family member A

Human Gene Id：605

Human Swiss Prot No：Q4VC05

Mouse Gene Id：77045

Mouse Swiss Prot No：Q9CXE2

Immunogen：The antiserum was produced against synthesized peptide derived from human BCL7A. AA range:21-70

Specificity：Bcl-7a Polyclonal Antibody detects endogenous levels of Bcl-7a protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：BCL7A;B-cell CLL/lymphoma 7 protein family member A

Observed Band(KD)：22kD

Background： This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Function：disease:Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the BCL7 family.,

Expression： Brain,Thalamus,