Target：MC2-R

Fields：cAMP signaling pathway;Neuroactive ligand-receptor interaction;Aldosterone synthesis and secretion;Cortisol synthesis and secretion;Cushing syndrome

Gene Name：MC2R

Protein Name：Adrenocorticotropic hormone receptor

Human Gene Id：4158

Human Swiss Prot No：Q01718

Mouse Gene Id：17200

Mouse Swiss Prot No：Q64326

Immunogen：The antiserum was produced against synthesized peptide derived from human ACTHR. AA range:248-297

Specificity：MC2-R Polyclonal Antibody detects endogenous levels of MC2-R protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MC2R;ACTHR;Adrenocorticotropic hormone receptor;ACTH receptor;ACTH-R;Adrenocorticotropin receptor;Melanocortin receptor 2;MC2-R

Observed Band(KD)：34kD

Background： MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014],

Function：disease:Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.,function:Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with FALP/MRAP.,tissue specificity:Melanocytes and corticoadrenal tissue.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Melanocytes and corticoadrenal tissue.