Target：MC4-R

Fields：Neuroactive ligand-receptor interaction

Gene Name：MC4R

Protein Name：Melanocortin receptor 4

Human Gene Id：4160

Human Swiss Prot No：P32245

Mouse Gene Id：17202

Mouse Swiss Prot No：P56450

Rat Gene Id：25635

Rat Swiss Prot No：P70596

Immunogen：The antiserum was produced against synthesized peptide derived from human MC4R. AA range:281-330

Specificity：MC4-R Polyclonal Antibody detects endogenous levels of MC4-R protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MC4R;Melanocortin receptor 4;MC4-R

Observed Band(KD)：37kD

Background： The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010],

Function：disease:Defects in MC4R are a cause of autosomal dominant obesity [MIM:601665].,function:Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase.,online information:Melanocortin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with ATRNL1.,tissue specificity:Brain, placental, and gut tissues.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Brain, placental, and gut tissues.